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Hybrid Capture-based Genomic Profiling of Circulating Tumor DNA From Patients With Advanced Ovarian Cancer.

Pathology oncology research : POR - 1 Jan 2021

Shen Wenbin, Shan Boer, Liang Shanhui, Zhang Junling, Yu Yangyang, Zhang Yuzi, Wang Guoqiang, Bai Yuezong, Qian Bing, Lu Jin, Jiang Zhi

Abstract excerpt

Objective: We conducted this study to characterize somatic genomic alterations in circulating tumor DNA (ctDNA) from patients with ovarian cancer and compare GAs detected in ctDNA with tissue databases. Methods: Hybrid capture-next generation sequencing genomic profiling of 150 genes was performed on ctDNA from 138 patients with ovarian cancer with 1,500× sequencing depth. The GAs detected in ctDNA were compared...

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Aged
Aged, 80 and over
Circulating Tumor DNA
Genomics
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

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PMID: 34257528
DOI: 10.3389/pore.2021.581534
PMCID: PMC8262155

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