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Article

Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling

23 Jan 2018

Abstract excerpt

ABSTRACT Stem cells (SCs) drive mammary development, giving rise postnatally to an epithelial bilayer composed of luminal and basal myoepithelial cells. Dysregulation of SCs is thought to be at the origin of certain breast cancers; however, the molecular identity of SCs and the factors regulating their function remain poorly defined. We identified the transmembrane protein podoplanin (Pdpn) as a specific marker...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 29361573
DOI: 10.1242/dev.160382

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