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Article

Cost-effectiveness of Population-Based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 Mutation Testing in Unselected General Population Women.

Journal of the National Cancer Institute - 1 Jul 2018

Manchanda Ranjit, Patel Shreeya, Gordeev Vladimir S, Antoniou Antonis C, Smith Shantel, Lee Andrew, Hopper John L, MacInnis Robert J, Turnbull Clare, Ramus Susan J, Gayther Simon A, Pharoah Paul D P, Menon Usha, Jacobs Ian, Legood Rosa

Abstract excerpt

Background: The cost-effectiveness of population-based panel testing for high- and moderate-penetrance ovarian cancer (OC)/breast cancer (BC) gene mutations is unknown. We evaluate the cost-effectiveness of population-based BRCA1/BRCA2/RAD51C/RAD51D/BRIP1/PALB2 mutation testing compared with clinical criteria/family history (FH) testing in unselected general population women. Methods: A decision-analytic model...

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Identifiers

PMID: 29361001
DOI: 10.1093/jnci/djx265

Genes

BRCA1
BRCA2
PALB2
BRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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