Article
Cost-effectiveness of population screening for BRCA mutations in Ashkenazi jewish women compared with family history-based testing.
Journal of the National Cancer Institute - 1 Jan 2015
Manchanda Ranjit, Legood Rosa, Burnell Matthew, McGuire Alistair, Raikou Maria, Loggenberg Kelly, Wardle Jane, Sanderson Saskia, Gessler Sue, Side Lucy, Balogun Nyala, Desai Rakshit, Kumar Ajith, Dorkins Huw, Wallis Yvonne, Chapman Cyril, Taylor Rohan, Jacobs Chris, Tomlinson Ian, Beller Uziel, Menon Usha, Jacobs Ian
Abstract excerpt
BACKGROUND: Population-based testing for BRCA1/2 mutations detects the high proportion of carriers not identified by cancer family history (FH)-based testing. We compared the cost-effectiveness of population-based BRCA testing with the standard FH-based approach in Ashkenazi Jewish (AJ) women. METHODS: A decision-analytic model was developed to compare lifetime costs and effects amongst AJ women in the UK of BRCA...
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