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Article

Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.

The Journal of biological chemistry - 21 Jan 2011

Renigunta Aparna, Renigunta Vijay, Saritas Turgay, Decher Niels, Mutig Kerim, Waldegger Siegfried

Abstract excerpt

Tamm-Horsfall glycoprotein (THGP) or Uromodulin is a membrane protein exclusively expressed along the thick ascending limb (TAL) and early distal convoluted tubule (DCT) of the nephron. Mutations in the THGP encoding gene result in Familial Juvenile Hyperuricemic Nephropathy (FJHN), Medullary Cystic Kidney Disease type 2 (MCKD-2), and Glomerulocystic Kidney Disease (GCKD). The physicochemical and biological...

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Source

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Identifiers

PMID: 21081491
DOI: 10.1074/jbc.M110.149880
PMCID: PMC3023518

Genes

DCT

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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