Article
Cryopreserved neonatal hepatocytes may be a source for transplantation: Evaluation of functionality toward clinical use.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Mar 2018
Lee Charlotte A, Dhawan Anil, Iansante Valeria, Lehec Sharon, Khorsandi Shirin E, Filippi Celine, Walker Simon, Fernandez-Dacosta Raquel, Heaton Nigel, Bansal Sanjay, Mitry Ragai R, Fitzpatrick Emer
Abstract excerpt
Neonatal livers are a potential source of good-quality hepatocytes for clinical transplantation. We compared viability and function of neonatal hepatocytes (NHs) and adult hepatocytes (AHs) and report their clinical use both intraportally and in alginate microbeads. Following isolation from donor livers, hepatocyte function was assessed using albumin, alpha-1-antitrypsin, and factor VII. Metabolic function was...
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