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Article

A preliminary study for constructing a bioartificial liver device with induced pluripotent stem cell-derived hepatocytes

1 Jan 2012

Abstract excerpt

BACKGROUND: Bioartificial liver systems, designed to support patients with liver failure, are composed of bioreactors and functional hepatocytes. Immunological rejection of the embedded hepatocytes by the host immune system is a serious concern that crucially degrades the performance of the device. Induced pluripotent stem (iPS) cells are considered a desirable source for bioartificial liver systems, because...

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PMID: 23217363
DOI: 10.1186/1475-925x-11-93

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