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Article

A Mos1 transposase in vivo assay to screen new HIV-1 integrase inhibitors.

Genetica - 1 Apr 2018

Cancian Mariana, Loreto Elgion L S

Abstract excerpt

The integrase and transposase enzymes of retrovirus and transposons, respectively, share the catalytic DDE domain. In vitro assays showed that inhibitors of HIV-1 integrase generally inhibit the mariner Mos1 transposase. Using a Drosophila strain in which the mobilisation of the mariner element can be quantified by mosaic eyes, we showed that flies maintained in medium containing 210 µM to 4 mM of raltegravir, or...

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PMID: 29352755
DOI: 10.1007/s10709-018-0007-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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