Article
Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication.
PLoS genetics - 1 Oct 2011
Magwire Michael M, Bayer Florian, Webster Claire L, Cao Chuan, Jiggins Francis M
Abstract excerpt
To understand the molecular basis of how hosts evolve resistance to their parasites, we have investigated the genes that cause variation in the susceptibility of Drosophila melanogaster to viral infection. Using a host-specific pathogen of D. melanogaster called the sigma virus (Rhabdoviridae), we mapped a major-effect polymorphism to a region containing two paralogous genes called CHKov1 and CHKov2. In a panel...
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