Article
A mathematical model for IL-6-mediated, stem cell driven tumor growth and targeted treatment.
PLoS computational biology - 1 Jan 2018
Nazari Fereshteh, Pearson Alexander T, Nör Jacques Eduardo, Jackson Trachette L
Abstract excerpt
Targeting key regulators of the cancer stem cell phenotype to overcome their critical influence on tumor growth is a promising new strategy for cancer treatment. Here we present a modeling framework that operates at both the cellular and molecular levels, for investigating IL-6 mediated, cancer stem cell driven tumor growth and targeted treatment with anti-IL6 antibodies. Our immediate goal is to quantify the...
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