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AHRRhypomethylation, lung function, lung function decline and respiratory symptoms

18 Jan 2018

Abstract excerpt

Epigenome-wide association studies have shown a consistent association between smoking exposure and hypomethylation in the aryl hydrocarbon receptor repressor (AHRR) gene (cg05575921). We tested the hypothesis thatAHRRhypomethylation is associated with low lung function, steeper lung function decline, and respiratory symptoms in the general population. AHRRmethylation extent was measured in 9113 individuals from...

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PMID: 29348151
DOI: 10.1183/13993003.01512-2017

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