Article
Evaluation of a microarray-based genotyping assay for the rapid detection of cytochrome P450 2C19 *2 and *3 polymorphisms from whole blood using nanoparticle probes.
American journal of clinical pathology - 1 Oct 2011
Buchan Blake W, Peterson Jess F, Cogbill Christopher H, Anderson Dennis K, Ledford Joellen S, White Mary N, Quigley Neil B, Jannetto Paul J, Ledeboer Nathan A
Abstract excerpt
Numerous drugs such as clopidogrel have been developed to reduce coagulation or inhibit platelet function. The hepatic cytochrome P450 (CYP) pathway is involved in the conversion of clopidogrel to its active metabolite. A recent black-box warning was included in the clopidogrel package insert indicating a significant clinical link between specific CYP2C19 genetic variants and poor metabolism of clopidogrel. Of...
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