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Article

Evolutionary history and adaptation from high-coverage whole-genome sequences of diverse African hunter-gatherers.

Cell - 3 Aug 2012

Lachance Joseph, Vernot Benjamin, Elbers Clara C, Ferwerda Bart, Froment Alain, Bodo Jean-Marie, Lema Godfrey, Fu Wenqing, Nyambo Thomas B, Rebbeck Timothy R, Zhang Kun, Akey Joshua M, Tishkoff Sarah A

Abstract excerpt

To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We identify 13.4 million variants, substantially increasing the set of known human variation. We found...

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Identifiers

PMID: 22840920
DOI: 10.1016/j.cell.2012.07.009
PMCID: PMC3426505

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