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Article

Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.

Pediatric research - 1 May 2018

Gordon Leslie B, Campbell Susan E, Massaro Joseph M, D'Agostino Ralph B, Kleinman Monica E, Kieran Mark W, Moses Marsha A

Abstract excerpt

BackgroundHutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare, fatal, segmental premature aging syndrome caused by the aberrant lamin A protein, progerin. The protein farnesyltransferase inhibitor, lonafarnib, ameliorates some aspects of cardiovascular and bone disease.MethodsWe performed a prospective longitudinal survey of plasma proteins in 24 children with HGPS (an estimated 10% of the world's...

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PMID: 29342131
DOI: 10.1038/pr.2018.9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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