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Article

Role of Chromatin Damage and Chromatin Trapping of FACT in Mediating the Anticancer Cytotoxicity of DNA-Binding Small-Molecule Drugs.

Cancer research - 15 Mar 2018

Nesher Elimelech, Safina Alfiya, Aljahdali Ieman, Portwood Scott, Wang Eunice S, Koman Igor, Wang Jianmin, Gurova Katerina V

Abstract excerpt

Precisely how DNA-targeting chemotherapeutic drugs trigger cancer cell death remains unclear, as it is difficult to separate direct DNA damage from other effects in cells. Recent work on curaxins, a class of small-molecule drugs with broad anticancer activity, shows that they interfere with histone-DNA interactions and destabilize nucleosomes without causing detectable DNA damage. Chromatin damage caused by...

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Identifiers

PMID: 29339544
DOI: 10.1158/0008-5472.CAN-17-2690
PMCID: PMC5856628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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