Targeted knockout of a chemokine-like gene increases anxiety and fear responses.

doi:10.1073/pnas.1707663115

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Article

Targeted knockout of a chemokine-like gene increases anxiety and fear responses.

Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018

Choi Jung-Hwa, Jeong Yun-Mi, Kim Sujin, Lee Boyoung, Ariyasiri Krishan, Kim Hyun-Taek, Jung Seung-Hyun, Hwang Kyu-Seok, Choi Tae-Ik, Park Chul O, Huh Won-Ki, Carl Matthias, Rosenfeld Jill A, Raskin Salmo, Ma Alan, Gecz Jozef, Kim Hyung-Goo, Kim Jin-Soo, Shin Ho-Chul, Park Doo-Sang, Gerlai Robert, Jamieson Bradley B, Kim Joon S, Iremonger Karl J, Lee Sang H, Shin Hee-Sup, Kim Cheol-Hee

Abstract excerpt

Emotional responses, such as fear and anxiety, are fundamentally important behavioral phenomena with strong fitness components in most animal species. Anxiety-related disorders continue to represent a major unmet medical need in our society, mostly because we still do not fully understand the mechanisms of these diseases. Animal models may speed up discovery of these mechanisms. The zebrafish is a highly...

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PMID: 29339520
DOI: 10.1073/pnas.1707663115
PMCID: PMC5798319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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