Article
Human airway branch variation and chronic obstructive pulmonary disease.
Proceedings of the National Academy of Sciences of the United States of America - 30 Jan 2018
Smith Benjamin M, Traboulsi Hussein, Austin John H M, Manichaikul Ani, Hoffman Eric A, Bleecker Eugene R, Cardoso Wellington V, Cooper Christopher, Couper David J, Dashnaw Stephen M, Guo Jia, Han MeiLan K, Hansel Nadia N, Hughes Emlyn W, Jacobs David R, Kanner Richard E, Kaufman Joel D, Kleerup Eric, Lin Ching-Long, Liu Kiang, Lo Cascio Christian M, Martinez Fernando J, Nguyen Jennifer N, Prince Martin R, Rennard Stephen, Rich Stephen S, Simon Leora, Sun Yanping, Watson Karol E, Woodruff Prescott G, Baglole Carolyn J, Barr R Graham
Abstract excerpt
Susceptibility to chronic obstructive pulmonary disease (COPD) beyond cigarette smoking is incompletely understood, although several genetic variants associated with COPD are known to regulate airway branch development. We demonstrate that in vivo central airway branch variants are present in 26.5% of the general population, are unchanged over 10 y, and exhibit strong familial aggregation. The most common airway...
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