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Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2018

Hong Chi-Chen, Sucheston-Campbell Lara E, Liu Song, Hu Qiang, Yao Song, Lunetta Kathryn L, Haddad Stephen A, Ruiz-Narváez Edward A, Bensen Jeannette T, Cheng Ting-Yuan David, Bandera Elisa V, Rosenberg Lynn A, Haiman Christopher A, Lee Kelvin, Evans Sharon S, Abrams Scott I, Repasky Elizabeth A, Olshan Andrew F, Palmer Julie R, Ambrosone Christine B

Abstract excerpt

Background: Constitutional immunity shaped by exposure to endemic infectious diseases and parasitic worms in Sub-Saharan Africa may play a role in the etiology of breast cancer among African American (AA) women.Methods: A total of 149,514 gene variants in 433 genes across 45 immune pathways were analyzed in the AMBER consortium among 3,663 breast cancer cases and 4,687 controls. Gene-based pathway analyses were...

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Autoimmune Diseases
Black or African American
DNA-Activated Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Kinase Kinase 1

Protein Interaction Maps

Receptors, Estrogen

Toll-Like Receptor 6

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PMID: 29339359
DOI: 10.1158/1055-9965.EPI-17-0434
PMCID: PMC5835191

Genes

BCL3
MAPK3
PRKDC
TLR6
TRAF1

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