Article
Uncontrolled asthmatics have increased FceRI+ and TGF-β-positive MCTC mast cells and collagen VI in the alveolar parenchyma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2018
Andersson C K, Weitoft M, Rydell-Törmänen K, Bjermer L, Westergren-Thorsson G, Erjefält J S
Abstract excerpt
BACKGROUND: Asthma has been associated with increased collagen deposition in both conducting airways and alveolar parenchyma. Mast cells (MCs) are key effector cells in asthma and have the ability to affect collagen synthesis. However, the link between clinical control and changes in bronchial and alveolar MC phenotypes and specific collagens in controlled and uncontrolled asthma remains unknown. OBJECTIVE: To...
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