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Article

High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia.

Scientific reports - 12 Jan 2018

Steeghs Elisabeth M P, Bakker Marjolein, Hoogkamer Alex Q, Boer Judith M, Hartman Quirine J, Stalpers Femke, Escherich Gabriele, de Haas Valerie, de Groot-Kruseman Hester A, Pieters Rob, den Boer Monique L

Abstract excerpt

Approximately 25% of the pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cases are genetically unclassified. More thorough elucidation of the pathobiology of these genetically unclassified ('B-other') cases may identify novel treatment options. We analyzed gene expression profiles of 572 pediatric BCP-ALL cases, representing all major ALL subtypes. High expression of STAP1, an adaptor protein...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fusion Proteins, bcr-abl

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptors, Antigen, B-Cell

Share to RNA Interference

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Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 29330417
DOI: 10.1038/s41598-017-17704-4
PMCID: PMC5766593

Genes

STAP1
BCR
ABL1
DUX4
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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