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Article

Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis.

PloS one - 1 Jan 2018

Lavtar Polona, Rudolf Gorazd, Maver Aleš, Hodžić Alenka, Starčević Čizmarević Nada, Živković Maja, Šega Jazbec Saša, Klemenc Ketiš Zalika, Kapović Miljenko, Dinčić Evica, Raičević Ranko, Sepčić Juraj, Lovrečić Luca, Stanković Aleksandra, Ristić Smiljana, Peterlin Borut

Abstract excerpt

Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their...

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Source

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Identifiers

PMID: 29324865
DOI: 10.1371/journal.pone.0190601
PMCID: PMC5764259

Genes

CLOCK
BMAL1

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