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Article

Circadian rhythmicity of symptomatic phenotypes in multiple sclerosis: the CircaMS study protocol and feasibility of biomarker collection.

BMJ open - 5 Mar 2025

Taccardi Doriana, Gowdy Hailey G M, Li Vina Wenyu, Wing Ana Cristina, Baharnoori Moogeh, Finlayson Marcia, Ghasemlou Nader

Abstract excerpt

INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune neurological disease with a variable prognosis and unpredictable course. Fatigue, pain and low mood are common symptoms that tend to fluctuate in people with MS (pwMS). Disrupted circadian rhythms may have a role in the symptoms' variability. Distinguishing interindividual differences and temporal daily fluctuations in MS symptoms may help to define...

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Identifiers

PMID: 40044201
DOI: 10.1136/bmjopen-2024-095357
PMCID: PMC11883553

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