Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.

Annals of the American Thoracic Society - 1 Apr 2018

Blue Elizabeth, Louie Tin L, Chong Jessica X, Hebbring Scott J, Barnes Kathleen C, Rafaels Nicholas M, Knowles Michael R, Gibson Ronald L, Bamshad Michael J, Emond Mary J

Abstract excerpt

RATIONALE: Cystic fibrosis, like primary ciliary dyskinesia, is an autosomal recessive disorder characterized by abnormal mucociliary clearance and obstructive lung disease. We hypothesized that genes underlying the development or function of cilia may modify lung disease severity in persons with cystic fibrosis. OBJECTIVES: To test this hypothesis, we compared variants in 93 candidate genes in both upper and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cilia
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cystic Fibrosis

Share to Disease Progression

Share to Dyneins

Share to Genetic Association Studies

Share to Microtubule-Associated Proteins

Share to Respiratory Function Tests

Source

Open in PubMed Open full text

Identifiers

PMID: 29323929
DOI: 10.1513/AnnalsATS.201706-451OC
PMCID: PMC5879139

Genes

DNAH14
DNAAF3
DNAH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.PMID 29323929Read ↗

Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 PatientsSemantic proximity Read ↗

Variants in FAM13A are associated with chronic obstructive pulmonary disease.Semantic proximity Read ↗

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.Semantic proximity Read ↗

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosisSemantic proximity Read ↗

Lung disease modifier genes in cystic fibrosisSemantic proximity Read ↗

FAM13A is a modifier gene of cystic fibrosis lung phenotype regulating rhoa activity, actin cytoskeleton dynamics and epithelial-mesenchymal transition.Semantic proximity Read ↗

Biallelic variants in DNAH10 are associated with skeletal developmental abnormalities and ciliary dysfunction.Semantic proximity Read ↗

Association of lung function genes with chronic obstructive pulmonary disease.Semantic proximity Read ↗

Association of FAM13A polymorphisms with COPD and COPD-related phenotypes in Han Chinese.Semantic proximity Read ↗

Topological data analysis reveals genotype-phenotype relationships in primary ciliary dyskinesia.Semantic proximity Read ↗

The FAM13A Long Isoform Regulates Cilia Movement and Coordination in Airway Mucociliary TransportSemantic proximity Read ↗

IFRD1 modulates disease severity in cystic fibrosis through the regulation of neutrophil effector functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.