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Rapid Phenotypic Drug Susceptibility Testing of Mycobacterium tuberculosis Using Raman-Deuterium Isotope Probing.

Analytical chemistry - 30 Jun 2026

Mao Xin, Song Yiyan, Wang Jingkai, Yu Dawei, Hu Huijie, Xu Ping, Cao Yiwen, Zhang Zhiqiang, Xu Junchi, Huang Wei E, Song Yizhi

Abstract excerpt

Accurate and timely drug susceptibility testing (DST) is essential for tuberculosis (TB) management, especially given the global rise of multidrug-resistant Mycobacterium tuberculosis (MTB). However, conventional phenotypic DST (pDST) is reliable but time-consuming, while molecular assays may fail to detect resistance not associated with known mutations. Here, we report a rapid pDST method using single-cell Raman...

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PMID: 42319020
DOI: 10.1021/acs.analchem.6c01078

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DST
EMB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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