Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge.

doi:10.1038/s41598-017-18645-8

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Flavin Reductase Contributes to Pneumococcal Virulence by Protecting from Oxidative Stress and Mediating Adhesion and Elicits Protection Against Pneumococcal Challenge.

Scientific reports - 10 Jan 2018

Morozov Giora I, Porat Nurith, Kushnir Tatyana, Najmuldeen Hastyar, Adawi Asad, Chalifa-Caspi Vered, Benisty Rachel, Ohayon Ariel, Liron Ofir, Azriel Shalhevet, Malka Itai, Dotan Shahar, Portnoi Maxim, Piotrowski Andrew A, Kafka Daniel, Hajaj Barak, Fishilevich Tali, Shagan Marilou, Tal Michael, Ellis Ron, Morrison Donald A, Mitchell Andrea M, Mitchell Timothy J, Dagan Ron, Yesilkaya Hasan, Nebenzahl Yaffa Mizrachi

Abstract excerpt

Pneumococcal flavin reductase (FlaR) is known to be cell-wall associated and possess age dependent antigenicity in children. This study aimed at characterizing FlaR and elucidating its involvement in pneumococcal physiology and virulence. Bioinformatic analysis of FlaR sequence identified three-conserved cysteine residues, suggesting a transition metal-binding capacity. Recombinant FlaR (rFlaR) bound Fe2+ and...

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PMID: 29321514
DOI: 10.1038/s41598-017-18645-8
PMCID: PMC5762878

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