Article
An immunocapture-LC-MS-based assay for serum SPINK1 allows simultaneous quantification and detection of SPINK1 variants.
Analytical and bioanalytical chemistry - 1 Feb 2018
Ravela Suvi, Valmu Leena, Domanskyy Mykola, Koistinen Hannu, Kylänpää Leena, Lindström Outi, Stenman Jakob, Hämäläinen Esa, Stenman Ulf-Håkan, Itkonen Outi
Abstract excerpt
Pancreatic secretory trypsin inhibitor Kazal type 1 (SPINK1) is a 6420 Da peptide produced by the pancreas, but also by several other tissues and many tumors. Some mutations of the SPINK1 gene, like the one causing amino acid change N34S, have been shown to confer susceptibility to recurrent or chronic pancreatitis. Detection of such variants are therefore of clinical utility. So far SPINK1 variants have been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.