Article
Germline cancer susceptibility in individuals with melanoma.
Journal of the American Academy of Dermatology - 1 Aug 2024
Funchain Pauline, Ni Ying, Heald Brandie, Bungo Brandon, Arbesman Michelle, Behera Tapas R, McCormick Shelley, Song Jung Min, Kennedy Lucy Boyce, Nielsen Sarah M, Esplin Edward D, Nizialek Emily, Ko Jennifer, Diaz-Montero Claudia M, Gastman Brian, Stratigos Alexander J, Artomov Mykyta, Tsao Hensin, Arbesman Joshua
Abstract excerpt
BACKGROUND: Prior studies have estimated a small number of individuals with melanoma (2%-2.5%) have germline cancer predisposition, yet a recent twin study suggested melanoma has the highest hereditability among cancers. OBJECTIVE: To determine the incidence of hereditary melanoma and characterize the spectrum of cancer predisposition genes that may increase the risk of melanoma. METHODS: Four hundred individuals...
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