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Article

Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder.

Addiction biology - 1 Mar 2019

Salvatore Jessica E, Han Shizhong, Farris Sean P, Mignogna Kristin M, Miles Michael F, Agrawal Arpana

Abstract excerpt

Alcohol use disorder (AUD) is a heritable complex behavior. Due to the highly polygenic nature of AUD, identifying genetic variants that comprise this heritable variation has proved to be challenging. With the exception of functional variants in alcohol metabolizing genes (e.g. ADH1B and ALDH2), few other candidate loci have been confidently linked to AUD. Genome-wide association studies (GWAS) of AUD and other...

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Source

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Identifiers

PMID: 29316088
DOI: 10.1111/adb.12591
PMCID: PMC6037617

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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