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Article

Modeling the genetic relatedness of Plasmodium falciparum parasites following meiotic recombination and cotransmission.

PLoS computational biology - 1 Jan 2018

Wong Wesley, Wenger Edward A, Hartl Daniel L, Wirth Dyann F

Abstract excerpt

Unlike in most pathogens, multiple-strain (polygenomic) infections of P. falciparum are frequently composed of genetic siblings. These genetic siblings are the result of sexual reproduction and can coinfect the same host when cotransmitted by the same mosquito. The degree with which coinfecting strains are related varies among infections and populations. Because sexual recombination occurs within the mosquito,...

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PMID: 29315306
DOI: 10.1371/journal.pcbi.1005923
PMCID: PMC5777656

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