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Article

Effects of recombination on multi-drug resistance evolution in Plasmodium falciparum malaria.

PLoS computational biology - 1 Aug 2025

Tran Kien Trung, Nguyen Tran Dang, Weissman Daniel B, Li Eric Zhewen, Mok Sachel, Small-Saunders Jennifer L, Bousema Teun, Zupko Robert J, Tran Thu Nguyen-Anh, Boni Maciej F

Abstract excerpt

When multiple beneficial alleles at multiple loci are present in a population but not linked together in any one individual, there is no general evolutionary result that determines whether recombination will speed up or slow down the emergence and evolution of genotypes carrying multiple beneficial alleles. Translated to infectious disease control, this evolutionary uncertainty means that when multiple types of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40853961
DOI: 10.1371/journal.pcbi.1013401
PMCID: PMC12377563

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