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Article

Type I interferons instigate fetal demise after Zika virus infection

5 Jan 2018

Abstract excerpt

littermates continue to develop. Analyses of the fetus and placenta revealed that, after ZIKV infection, IFNAR signaling in the conceptus inhibits development of the placental labyrinth, resulting in abnormal architecture of the maternal-fetal barrier. Exposure of midgestation human chorionic villous explants to type I IFN, but not type III IFNs, altered placental morphology and induced cytoskeletal...

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PMID: 29305462
DOI: 10.1126/sciimmunol.aao1680

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