Article
Generation of GPI-linked CCL5 based chemokine receptor antagonists for the suppression of acute vascular damage during allograft transplantation.
Protein engineering, design & selection : PEDS - 1 Jan 2006
Notohamiprodjo Mike, Djafarzadeh Roghieh, Mojaat Anke, von Lüttichau Irene, Gröne Hermann-Josef, Nelson Peter J
Abstract excerpt
Limiting the acute vascular damage associated with leukocyte infiltration is a central issue in solid organ transplantation. The family of chemotactic cytokines (chemokines) helps to regulate leukocyte recruitment. Systemic treatment with the chemokine ligand-5 (CCL5) based antagonist Met-RANTES has previously shown to suppress acute damage to transplanted kidneys by blocking effector cell recruitment. To address...
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