Article
Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Liver international : official journal of the International Association for the Study of the Liver - 1 May 2018
Asuri Sirisha, McIntosh Sarah, Taylor Valerie, Rokeby Andrew, Kelly James, Shumansky Karey, Field Lanora Leigh, Yoshida Eric M, Arbour Laura
Abstract excerpt
BACKGROUND & AIMS: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterized by destruction of intrahepatic bile ducts, portal inflammation and cirrhosis. Although rare in most populations, it is prevalent and often familial in British Columbia First Nations. We hypothesized that major genetic factors increased the risk in First Nations. METHODS: In all, 44 individuals with Primary...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.