Article
Repositioning drugs by targeting network modules: a Parkinson's disease case study.
BMC bioinformatics - 28 Dec 2017
Yue Zongliang, Arora Itika, Zhang Eric Y, Laufer Vincent, Bridges S Louis, Chen Jake Y
Abstract excerpt
BACKGROUND: Much effort has been devoted to the discovery of specific mechanisms between drugs and single targets to date. However, as biological systems maintain homeostasis at the level of functional networks robustly controlling the internal environment, such networks commonly contain multiple redundant mechanisms designed to counteract loss or perturbation of a single member of the network. As such,...
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