Article

Finding drug targeting mechanisms with genetic evidence for Parkinson’s disease

2020-07-24

Abstract excerpt

<h4>Summary</h4> Parkinson’s disease (PD) is a neurodegenerative movement disorder that currently has no disease-modifying treatment, partly owing to inefficiencies in drug target identification and validation using human evidence. Here, we use Mendelian randomization to investigate more than 3000 genes that encode druggable proteins, seeking to predict their efficacy as drug targets for PD. We use expression and...

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Literature Corpus work: caa2eed8-488e-5b89-afab-57918e7da7a9
DOI: 10.1101/2020.07.24.208975

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