A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies.

doi:10.1016/j.eururo.2017.04.034

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A Prostate Cancer "Nimbosus": Genomic Instability and SChLAP1 Dysregulation Underpin Aggression of Intraductal and Cribriform Subpathologies.

European urology - 1 Nov 2017

Chua Melvin L K, Lo Winnie, Pintilie Melania, Murgic Jure, Lalonde Emilie, Bhandari Vinayak, Mahamud Osman, Gopalan Anuradha, Kweldam Charlotte F, van Leenders Geert J L H, Verhoef Esther I, Hoogland Agnes Marije, Livingstone Julie, Berlin Alejandro, Dal Pra Alan, Meng Alice, Zhang Junyan, Orain Michèle, Picard Valérie, Hovington Hélène, Bergeron Alain, Lacombe Louis, Fradet Yves, Têtu Bernard, Reuter Victor E, Fleshner Neil, Fraser Michael, Boutros Paul C, van der Kwast Theodorus H, Bristow Robert G

Abstract excerpt

BACKGROUND: Intraductal carcinoma (IDC) and cribriform architecture (CA) represent unfavorable subpathologies in localized prostate cancer. We recently showed that IDC shares a clonal ancestry with the adjacent glandular adenocarcinoma. OBJECTIVE: We investigated for the co-occurrence of "aggression" factors, genomic instability and hypoxia, and performed gene expression profiling of these tumors. DESIGN,...

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PMID: 28511883
DOI: 10.1016/j.eururo.2017.04.034

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