Article
The genomic landscape of two Burkitt lymphoma cases and derived cell lines: comparison between primary and relapse samples.
Leukemia & lymphoma - 1 Sept 2018
Wever Claudia M, Geoffrion Dominique, Grande Bruno M, Yu Stephen, Alcaide Miguel, Lemaire Maryse, Riazalhosseini Yasser, Hébert Josée, Gavino Christina, Vinh Donald C, Petrogiannis-Haliotis Tina, Dmitrienko Svetlana, Mann Koren K, Morin Ryan D, Johnson Nathalie A
Abstract excerpt
Relapse occurs in 10-40% of Burkitt lymphoma (BL) patients that have completed intensive chemotherapy regimens and is typically fatal. While treatment-naive BL has been characterized, the genomic landscape of BL at the time of relapse (rBL) has never been reported. Here, we present a genomic characterization of two rBL patients. The diagnostic samples had mutations common in BL, including MYC and CCND3....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.