Article
Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.
The Journal of infectious diseases - 27 Dec 2017
de Vries Rory D, Nieuwkoop Nella J, van der Klis Fiona R M, Koopmans Marion P G, Krammer Florian, Rimmelzwaan Guus F
Abstract excerpt
Influenza A virus (IAV) and influenza B virus (IBV) cause substantial morbidity and mortality during annual epidemics. Two distinct lineages of IBV are distinguished, based on variation in hemagglutinin (HA): B/Victoria/2/87-like (B/Vic) and B/Yamagata/16/88-like (B/Yam). Here, we show that, in humans, primary IBV infection with either lineage induces HA-specific antibody-dependent cellular cytotoxicity...
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