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Article

Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway.

PloS one - 1 Jan 2018

Fan Fan, Wang Rui, Boulbes Delphine R, Zhang Huiyuan, Watowich Stephanie S, Xia Ling, Ye Xiangcang, Bhattacharya Rajat, Ellis Lee M

Abstract excerpt

BACKGROUND: There is conflicting data on the role of macrophages in colorectal cancer (CRC); some studies have shown that macrophages can exert an anti-tumor effect whereas others show that macrophages are tumor promoting. We sought to determine the role of conditioned medium (CM) from macrophages, in particular classically activated macrophages, on the development of the CSC phenotype in CRC cells, which is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29293549
DOI: 10.1371/journal.pone.0190070
PMCID: PMC5749743

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SHH

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