Article
Lipopolysaccharide supports maintaining the stemness of CD133(+) hepatoma cells through activation of the NF-κB/HIF-1α pathway.
Cancer letters - 10 Aug 2016
Lai Fo-Bao, Liu Wen-Ting, Jing Ying-Ying, Yu Guo-Feng, Han Zhi-Peng, Yang Xue, Zeng Jian-Xing, Zhang Hang-Jie, Shi Rong-Yu, Li Xiao-Yong, Pan Xiao-Rong, Li Rong, Zhao Qiu-Dong, Wu Meng-Chao, Zhang Ping, Liu Jing-Feng, Wei Li-Xin
Abstract excerpt
Due to the existence of cancer stem cells (CSCs), persistence and relapse of human hepatocellular carcinoma (HCC) are common after treatment with existing anti-cancer therapies. Emerging evidence indicates that lipopolysaccharide (LPS) plays a crucial role in aggravating HCC, but information about the effect of LPS on CSCs of HCC remains scant. Here, we report that the stemness of CD133(+) CSCs sorted from the...
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