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Article

Single nucleotide polymorphism of Methyl-CpG-binding protein 2 gene associates with juvenile idiopathic arthritis.

Clinical rheumatology - 1 Feb 2018

Mahmoudi Mahdi, Hamzeh Elham, Aslani Saeed, Ziaee Vahid, Poursani Shiva, Rezaei Nima

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is a transcription suppressor or activator, acting through binding to methylated DNA. Numerous investigations have established a role for methylation aberrancies in the pathogenesis of autoimmune disorders. Single nucleotide polymorphisms (SNPs) in MECP2 gene have been implicated with susceptibility to rheumatoid arthritis (RA). Here, the plausible association of MECP2 gene...

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Identifiers

PMID: 29288368
DOI: 10.1007/s10067-017-3968-z

Genes

MECP2

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