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Article

Cytotoxic granule endocytosis depends on the Flower protein.

The Journal of cell biology - 5 Feb 2018

Chang Hsin-Fang, Mannebach Stefanie, Beck Andreas, Ravichandran Keerthana, Krause Elmar, Frohnweiler Katja, Fecher-Trost Claudia, Schirra Claudia, Pattu Varsha, Flockerzi Veit, Rettig Jens

Abstract excerpt

Cytotoxic T lymphocytes (CTLs) kill target cells by the regulated release of cytotoxic substances from granules at the immunological synapse. To kill multiple target cells, CTLs use endocytosis of membrane components of cytotoxic granules. We studied the potential calcium dependence of endocytosis in mouse CTLs on Flower, which mediates the calcium dependence of synaptic vesicle endocytosis in Drosophila...

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Identifiers

PMID: 29288152
DOI: 10.1083/jcb.201706053
PMCID: PMC5800809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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