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Article

Systematic mutagenesis of α-synuclein reveals distinct sequence requirements for physiological and pathological activities.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Oct 2012

Burré Jacqueline, Sharma Manu, Südhof Thomas C

Abstract excerpt

α-Synuclein is an abundant presynaptic protein that binds to phospholipids and synaptic vesicles. Physiologically, α-synuclein functions as a SNARE-protein chaperone that promotes SNARE-complex assembly for neurotransmitter release. Pathologically, α-synuclein mutations and α-synuclein overexpression cause Parkinson's disease, and aggregates of α-synuclein are found as Lewy bodies in multiple neurodegenerative...

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Identifiers

PMID: 23100443
DOI: 10.1523/JNEUROSCI.3545-12.2012
PMCID: PMC3506191

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