Article
NF-κB-regulated miR-155, via repression of QKI, contributes to the acquisition of CSC-like phenotype during the neoplastic transformation of hepatic cells induced by arsenite.
Molecular carcinogenesis - 1 Apr 2018
Chen Chao, Luo Fei, Yang Qianlei, Wang Dapeng, Yang Ping, Xue Junchao, Dai Xiangyu, Liu Xinlu, Xu Hui, Lu Jiachun, Zhang Aihua, Liu Qizhan
Abstract excerpt
Chronic exposure to arsenite can cause various human tumors. For the initiation and recurrence of human liver cancer, the acquisition of CSC-like properties is essential. In various cancers, microRNAs (miRNAs) act as regulators in induction of CSC-like properties. Liver cancers over-express miR-155, but the mechanism relating miR-155 and arsenite-induced liver cancer is unknown. Here, we show that long-term...
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