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Article

A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40.

Neoplasia (New York, N.Y.) - 1 Feb 2018

Ngernyuang Nipaporn, Yan Wei, Schwartz Lawrence M, Oh Dennis, Liu Ying-Bin, Chen Hongzhuan, Shao Rong

Abstract excerpt

The heparin-binding glycoprotein YKL-40 (CHI3L1) is intimately associated with microvascularization in multiple human diseases including cancer and inflammation. However, the heparin-binding domain(s) pertinent to the angiogenic activity have yet been identified. YKL-40 harbors a consensus heparin-binding motif that consists of positively charged arginine (R) and lysine (K) (RRDK; residues 144-147); but they...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29274508
DOI: 10.1016/j.neo.2017.11.011
PMCID: PMC5773473

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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