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Article

Upregulation of YKL-40 Promotes Metastatic Phenotype and Correlates with Poor Prognosis and Therapy Response in Patients with Colorectal Cancer.

Cells - 11 Nov 2022

De Robertis Mariangela, Greco Maria Raffaella, Cardone Rosa Angela, Mazza Tommaso, Marzano Flaviana, Mehterov Nikolay, Kazakova Maria, Belev Nikolay, Tullo Apollonia, Pesole Graziano, Sarafian Victoria, Signori Emanuela

Abstract excerpt

YKL-40 is a heparin- and chitin-binding glycoprotein that belongs to the family of glycosyl hydrolases but lacks enzymatic properties. It affects different (patho)physiological processes, including cancer. In different tumors, YKL-40 gene overexpression has been linked to higher cell proliferation, angiogenesis, and vasculogenic mimicry, migration, and invasion. Because, in colorectal cancer (CRC), the...

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Identifiers

PMID: 36428997
DOI: 10.3390/cells11223568
PMCID: PMC9688424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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