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Article

Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018

Little Michael S, Pellock Samuel J, Walton William G, Tripathy Ashutosh, Redinbo Matthew R

Abstract excerpt

The gut microbiota harbor diverse β-glucuronidase (GUS) enzymes that liberate glucuronic acid (GlcA) sugars from small-molecule conjugates and complex carbohydrates. However, only the Enterobacteriaceae family of human gut-associated Proteobacteria maintain a GUS operon under the transcriptional control of a glucuronide repressor, GusR. Despite its potential importance in Escherichia, Salmonella, Klebsiella,...

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Source

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Identifiers

PMID: 29269393
DOI: 10.1073/pnas.1716241115
PMCID: PMC5777068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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