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Article

Complex II phosphorylation is triggered by unbalanced redox homeostasis in cells lacking complex III.

Biochimica et biophysica acta. Bioenergetics - 1 Mar 2018

Tropeano Concetta Valentina, Fiori Jessica, Carelli Valerio, Caporali Leonardo, Daldal Fevzi, Ghelli Anna Maria, Rugolo Michela

Abstract excerpt

A marked stimulation of complex II enzymatic activity was detected in cybrids bearing a homoplasmic MTCYB microdeletion causing disruption of both the activity and the assembly of complex III, but not in cybrids harbouring another MTCYB mutation affecting only the complex III activity. Moreover, complex II stimulation was associated with SDHA subunit tyrosine phosphorylation. Despite the lack of detectable...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29269267
DOI: 10.1016/j.bbabio.2017.12.003
PMCID: PMC5913658

Genes

SDHA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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