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Article

Curcumin Protects SDH2 Mutant from Oxidative Stress and Improves Mitochondrial Function: Application Potential for Complex II Deficiency.

International journal of molecular sciences - 10 Jun 2026

Liu Yi, Wang Na, Cai Heng

Abstract excerpt

Complex II deficiency is a rare inherited mitochondrial disorder characterized by structural and functional deficiency of complex II, for which there is currently no definitive drug treatment. Curcumin is a polyphenolic compound with antioxidant, anti-inflammatory, anti-tumor, and anti-aging properties. By constructing a mutant strain of the Saccharomyces cerevisiaeSDH2 gene, we can mimic the functional defects...

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Share to Antioxidants
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Complex II

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Source

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Identifiers

PMID: 42352974
DOI: 10.3390/ijms27125253
PMCID: PMC13299523

Genes

SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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