Article
Osteosarcoma arising in fibrous dysplasia, confirmed by mutational analysis of GNAS gene.
Pathology, research and practice - 1 Feb 2018
Sugiura Yoshiya, Kanda Hiroaki, Motoi Noriko, Nomura Kimie, Inamura Kentaro, Okada Erina, Matsumoto Haruna, Shimoji Takashi, Matsumoto Seiichi, Nakayama Jun, Takazawa Yutaka, Ishikawa Yuichi, Machinami Rikuo
Abstract excerpt
Malignancy arising in fibrous dysplasia (FD) is rare. Approximately 100 cases have been reported so far, and osteosarcoma is the most common malignancy. We report a case of osteosarcoma in a 33-year-old Japanese man with monostotic FD of the right proximal femur from the age of 16 years. Histologically, relatively well-differentiated osteosarcoma was found in the FD lesion. Immunohistochemically, the FD was...
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